Cover Article
MicroRNAs—Versatile Regulators of Gene Networks
This class of genes, discovered within the last decade, is of increasing relevance to various disease states, including glioblastoma and synaptic plasticity, said Kenneth S. Kosik, MD, at the 133rd Annual Meeting of the American Neurological Association

Cover Article
High Rate of Posttraumatic Epilepsy Is Expected in Iraq War Veterans
According to research presented at the 133rd Annual Meeting of the American Neurological Association, the rate of traumatic brain injury-induced epilepsy is likely to increase, with no clearly effective strategy available to treat or prevent it.

Cover Article
Excessive Use of Some Analgesics May Lead to Transformed or Chronic Migraine
Certain classes of analgesics may cause headache pain when used excessively, and such use of these medications should be considered a risk factor for transformed or chronic migraine, according to Marcelo E. Bigal, MD, PhD, at the 50th Annual Scientific Meeting of the American Headache Society.

Cover Article
Managing Childhood Headache in the Emergency Department
It is important to know when to refer a child to the emergency department for migraine. Migraine is diagnosed correctly in 18% to 21% of children in the emergency department, but there are a lot of gaps in other diagnoses.

Selected Articles

• Red Flags in Neurologic Examinations Point to MS
• News Roundup: Late-Breaking Neurologic News
• Assessing Treatment Options for Patients With Nocturnal Awakenings
• Habitual Tea Consumption Is Associated With Better Cognitive Function in ParkinsonÕs Disease
• Gastrointestinal Bleeding After Stroke Increases Mortality Rate—And Other Recent Articles of Interest in Neurology

Cover Article
Challenging the Status Quo in Understanding MS
Research from the 22nd Annual Meeting of the Consortium of Multiple Sclerosis challenges the notion that MS is mainly a white matter disease and states that gray matter pathology is a larger component.

Selected Articles

• DreamingÑAn Altered State of Consciousness
• News Roundup: Late-Breaking Neurologic News
• Low-dose t-PA Improves Outcome in Patients With Intracerebral Hemorrhage
• Understanding the Neurons Involved in Inducing Sleep
• Nonadherence to AEDs Increases Mortality—And Other Recent Articles of Interest in Neurology

Cover Article
Is There an Underlying Biologic Relationship Between Parkinson's Disease and Diabetes?
Patients with diabetes have a higher risk for Parkinson's disease; however, researchers discover contradictory findings.

Selected Articles

• Hypertension Linked to MCI Risk in Elderly Patients
• News Roundup: Late-Breaking Neurologic News
• Statins May Not Protect Against Alzheimer's Disease-Related Decline
• Cognitive Side Effects of Chemotherapy May Be Attributable to CNS Damage
• Conventional NSAIDs Have Similar Protective Effect for Alzheimer's Disease—And Other Recent Articles of Interest in Neurology

Cover Article
Men Are More Likely to Have Mild Cognitive Impairment
Research presented at the 60th Annual Meeting of the American Academy of Neurology states that men are 44% more likely to have mild cognitive impairment compared to women.

Selected Articles

• Exercise Lowers Risk for Mild Cognitive Impairment
• News Roundup: Late-Breaking Neurologic News
• Formaldehyde Exposure May Pose Risk for Amyotrophic Lateral Sclerosis
• Reversible Cerebral Vasoconstriction Syndromes Are Frequently Confused With CNS Vasculitis
• Cardiovascular Disease in Women Is Unaffected by Folic Acid and B Vitamins—And Other Recent Articles of Interest in Neurology

Cover Article
Advances in Neurogenetics, Neuromics Aid Understanding of Neurologic Disorders
Studies involving genetic risk factors for Alzheimer's disease, single-gene neurogenetic disorders, parental relationships among patients with MS, and malformations of cortical development in children.

Selected Articles

• Developing Biomarkers for ParkinsonÕs Disease
• News Roundup: Late-Breaking Neurologic News
• Resuming Rehabilitation Therapy After Stroke
• When Should Physicians Test for Dangerous Headache?
• Stenting Procedures Equivalent in Safety and Efficacy in High-Risk Patients—And Other Recent Articles of Interest in Neurology

Cover Article
Obesity Associated With Increased Stroke Risk in Middle-Aged Women
Increase in BMI and waist circumferance have correlated with increase in stroke in women while incidence of stroke in men remains the same.

Selected Articles

• A Novel Option for Migraine Prevention?
• News Roundup: Late-Breaking Neurologic News
• Depression, Aggression, and Sleep Disturbances Commonly Occur in Patients Following TBI
• Timing of Estrogen Replacement Initiation May Be Imortant in Reeducing Stroke Risk
• Larger Midsection in Midlife Increases Dementia Risk—And Other Recent Articles of Interest in Neurology

Cover Article
FDA Warns of Suicide Risk With Antiepileptic Drugs
The FDA has issued an alert to health care professionals, warning that patients who take antiepileptic drugs have approximately double the risk of suicidal behavior or ideation compared with patients given placebo.

Selected Articles

• New Guideline Focuses on Accidental Falls
• News Roundup: Late-Breaking Neurologic News
• Aripiprazole Improves Symptoms of Aggression in Tourette Disorder
• Unexpected MS—MRI Findings in Asymptomatic Patients May Predict Clinical Conversion
• Certain Antihypertensive Drugs May Reduce Risk of Parkinson's Disease—And Other Recent Articles of Interest in Neurology

Cover Article
Multiple Genetic Factors May Lead to Alzheimer's Disease
Plasma β-amyloid levels are significantly elevated in first-degree relatives of patients with late-onset Alzheimer's disease, and increase not attributable to APOE ε4 or to pathogenic coding mutations in the known early-onset Alzheimer's disease genes, researchers reported in the February 19 Neurology.

Selected Articles

• Can Genotypes Predict Response to MS Treatment?
• News Roundup: Late-Breaking Neurologic News
• Chronic Daily HeadacheÑA Challenge for Pediatric Neurologists and Psychiatrists
• Poor AED Compliance May Lead to Seizures and Dosage Increases in Children with Epilepsy
• Patients With Very Mild Dementia May Be Able to Drive Safely—And Other Recent Articles of Interest in Neurology

Cover Article
Does Specialized Care Lead to Improved Seizure Control in Epilepsy?
A study presented at the 61st Annual Meeting of the American Epilepsy Society indicates that improved seizure control is related not to medication factors but to the physicians' level of training and experience and that the improvement seen with care by epilepsy specialists occurs independently of what AED a patient takes.

Selected Articles

• Vaccine Shows Broad Coverage Against Meningitis
• News Roundup: Late-Breaking Neurologic News
• Looking Beyong t-PA for Effective Stroke Treatment
• Brain Imaging Links Cholesterol Levels in Midlife to Alzheimer's Disease Risk
• Combination Therapy for MS Is Safe and Effective—And Other Recent Articles of Interest in Neurology